A quick note on how I do pixel art for The Incident:
In Photoshop, I set up two views of the same document: one at natural size, the other zoomed in. I draw with a 1-pixel pencil brush (of course), picking from the Mac OS color palette.
There are two basic methods to learning pixel art: 1) Stare at classic game screenshots from MobyGames for a very long time. Playing the games is crucial, of course, but I find that looking at stills helps distill the style. How do they deal with the pixel limitations? How do you make a 16-pixel character look smitten, or annoyed, or tired? 2) As with all art, the best way to hone your skill is it to first copy the work of others, then draw from reference, then draw from memory and imagination.
I think I’ve clicked literally millions of pixels to canvas while working on this game. There are few things I enjoy doing more.